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Chromosomal rearrangements of the MLL gene are associated with high‐risk infant, pediatric, adult, and therapy‐induced acute leukemias. So far, about 80 different direct MLL fusions and about 120 reciprocal MLL fusions have been characterized at the molecular level. The common theme in these leukemia‐associated genetic rearrangements is the genetic disruption of the MLL gene. This leads to MLL‐X fusion...
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