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Osteoclasts (OCLs) are multinucleated bone‐resorbing cells that are differentiated by receptor activator of nuclear factor kappa‐B ligand (RANKL) and macrophage colony‐stimulating factor (M‐CSF). Our recent studies have shown that heme‐oxygenase‐1 (HO‐1), a stress‐induced cytoprotective enzyme, plays an important role in OCL differentiation, although the pharmacological significance of this effect...
Deltamethrin is a widely used pyrethroid pesticide. Although the cytotoxicity of deltamethrin has been reported, especially in neuronal cells, there is no information concerning the effects of deltamethrin on osteoclasts (OCLs). In this study, we showed that deltamethrin inhibited OCL differentiation in vitro. The effects of deltamethrin on OCL differentiation by receptor activator of nuclear factor...
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