Search results for: Eiji Oki

Items from 1 to 20 out of 291 results

article

Joint service placement and user assignment model in multi‐access edge computing networks against base‐station failure

Haruto Taka, Fujun He, Eiji Oki

International Journal of Network Management > 33 > 6 > n/a - n/a

Multi‐access edge computing (MEC) enables users to exploit the resources of cloud computing at a base station (BS) in proximity to the users where an MEC server is hosted. While we have advantage of being able to communicate with low latency and small network load in MEC networks, the resources in BSs are limited. One challenge is where to provide users with services from to make efficient use of...

article

Three‐dimensional imaging of intramural perineural invasion in colorectal cancer: Three‐dimensional reconstruction approach with multiple immunohistochemically stained sections

Yu Miyashita, Tetsuo Ikeda, Eiji Shinto, Shinji Okano, more

Pathology International > 72 > 5 > 293 - 299

Perineural invasion (PNI) at Auerbach's plexus in colorectal cancer (CRC), known as intramural PNI, is associated with adverse prognostic outcomes. This study aimed to characterize the three‐dimensional (3D) architecture of CRC with intramural PNI and to evaluate the morphological features of tumor invasion around nerve tissue. Serial tissue sections from two cases of CRC were stained with cytokeratin...

article

Histological categorisation of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma

Akihiro Sakai, Yuichiro Nakashima, Yu Miyashita, Tadakazu Ao, more

Histopathology > 79 > 2 > 219 - 226

Aims Histological categorisation of the desmoplastic reaction (DR) is an independent prognostic factor in colorectal cancer. However, it is unknown whether DR categorisation is predictive of oesophageal squamous cell carcinoma (OSCC) outcomes. This study aimed to evaluate the prognostic value of DR categorisation in OSCC patients. Methods and results Data were collected from 118 patients with OSCC...

article

Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses

Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Yoko Ogata, more

International Journal of Cancer > 148 > 5 > 1260 - 1275

Microsatellite instability (MSI) is categorized by mutation frequency: high MSI (MSI‐H), low MSI (MSI‐L) and microsatellite stable (MSS). MSI‐H tumors have a distinct immunogenic phenotype, with immunotherapies using checkpoint inhibitors already approved for the treatment of MSI‐H gastroesophageal adenocarcinoma (GEA); this is not observed for MSI‐L or MSS. Here, we tested the hypothesis that MSI‐L...

article

The evolution of surgical treatment for gastrointestinal cancers

Yoshihiko Maehara, Yuji Soejima, Tomoharu Yoshizumi, Naoyuki Kawahara, more

International Journal of Clinical Oncology > 2019 > 24 > 11 > 1333-1349

Introduction According to the latest Japanese nationwide estimates, over a million Japanese people are newly diagnosed with cancer each year. Since gastrointestinal cancers account for more than 40% of all cancer-related deaths, it is imperative to formulate effective strategies to control them. Materials and methods, and results Basic drug discovery research Our research has revealed that the abnormal...

article

Comparison of computed tomography imaging analyses for evaluation after chemotherapy in patients with colorectal cancer: a retrospective pooled analysis of six phase II clinical trials

Kosuke Hirose, Eiji Oki, Takayuki Shimose, Sanae Sakamoto, more

International Journal of Clinical Oncology > 2019 > 24 > 11 > 1397-1405

Background There are several methods for analyzing computed tomography (CT) images to evaluate chemotherapy efficacy in clinical studies. However, the optimal analysis method for each drug is still under debate. We conducted a pooled analysis using data from six phase II studies to evaluate four analysis methods in colorectal cancers (CRCs): morphological responses (MRs), early tumor shrinkage (ETS),...

article

CT gastrography “wall-carving technique” of gastric cancer: impact of contrast enhancement based on layer depth

Daisuke Tsurumaru, Yusuke Nishimuta, Toshio Muraki, Yoshiki Asayama, more

Japanese Journal of Radiology > 2019 > 37 > 8 > 597-604

Purpose Wall-carving technique (WC) is a special volume rendering technique of three-dimensional CT gastrography that can illustrate the enhancement of gastric wall at an arbitrary depth. We conducted the present study to evaluate the impact of contrast enhancement based on layer depth on WC of gastric cancer and to correlate them with pathological findings. Methods The subjects of this retrospective...

article

Skeletal muscle loss during systemic chemotherapy for colorectal cancer indicates treatment response: a pooled analysis of a multicenter clinical trial (KSCC 1605-A)

Shun Sasaki, Eiji Oki, Hiroshi Saeki, Takayuki Shimose, more

International Journal of Clinical Oncology > 2019 > 24 > 10 > 1204-1213

Background Sarcopenia or degenerative loss of skeletal muscle mass is related to poor prognosis in patients with cancer. This study aimed to clarify the clinical significance of skeletal muscle loss (SML) during chemotherapy for metastatic colorectal cancer (mCRC). Methods A total of 249 patients who were secondarily registered in a pooled database of mCRC patients with the first-line systemic chemotherapy...

article

Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report

Kosuke Hirose, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, more

Surgical Case Reports > 2019 > 5 > 1 > 1-8

Background Recurrences after radical esophagectomy are common. The prognosis for recurrent esophageal cancer is generally poor. Recurrences usually occur between 1 and 3 years of surgery, with the duration of median survival after recurrence ranging from 5 to 10 months. The number of sites and involved organs vary among patients. Consequently, a standard therapeutic strategy has not been established,...

article

Approach to problem of minimizing network power consumption based on robust optimization

Bimal Chandra Das, Satoshi Takahashi, Eiji Oki, Masakazu Muramatsu

International Journal of Communication Systems > 32 > 5 > n/a - n/a

In this paper, a green and robust optimization model is introduced to minimize network power consumption, which allows fluctuations of traffic demands between source‐destination pairs in the network. Our model is based on the green hose model, where the traffic is bounded by just total outgoing and incoming amount at each node. In addition to the green hose model, we use the ellipsoidal uncertainty...

article

C‐reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, more

Journal of Gastroenterology and Hepatology > 34 > 2 > 355 - 363

Background and Aim The C‐reactive protein (CRP)/albumin (Alb) ratio has been reported as a novel prognostic marker in several cancers. The objective of this study was to investigate the prognostic value of the CRP/Alb ratio in patients who underwent surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods Data for 144 patients who underwent surgery...

article

Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer

Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, more

Journal of Gastroenterology and Hepatology > 34 > 1 > 140 - 146

Background and Aim The amount of proteins and peptides can be estimated with amide proton transfer (APT) imaging. Previous studies demonstrated the usefulness of APT imaging to predict tumor malignancy. We determined whether APT imaging can predict the tumor response to neoadjuvant chemotherapy (NAC) in patients with locally advanced rectal cancer (LARC). Methods Seventeen patients with LARC who...

article

Primary amelanotic malignant melanoma of the esophagus: a case report

Naomichi Koga, Nobuhide Kubo, Hiroshi Saeki, Shun Sasaki, more

Surgical Case Reports > 2019 > 5 > 1 > 1-6

Background Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME. Case presentation An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. An endoscopic examination and constructed radiography revealed...

article

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer

Daisuke Hashimoto, Kota Arima, Shigeki Nakagawa, Yuji Negoro, more

Journal of Gastroenterology > 2019 > 54 > 5 > 437-448

Background After initial pancreatic resection, local recurrence of pancreatic cancer (PC) or new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this retrospective study was to clarify the clinical features and establish a treatment strategy for remnant PC. Methods A multicenter retrospective study with the Kyushu Study Group...

article

A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2)

Ken Kato, Taroh Satoh, Kei Muro, Takaki Yoshikawa, more

Gastric Cancer > 2019 > 22 > 2 > 344-354

Background Nivolumab, an anti-programmed death-1 agent, showed survival benefits in Asian patients, including Japanese, with gastric/gastro-esophageal junction (G/GEJ) cancer. We report the analysis of the Japanese subpopulation from ATTRACTION-2 that evaluated nivolumab versus placebo in unresectable advanced or recurrent G/GEJ cancer after ≥ 2 chemotherapy regimens. Methods Data from the Japanese...

article

Postoperative Skeletal Muscle Loss Predicts Poor Prognosis of Adenocarcinoma of Upper Stomach and Esophagogastric Junction

Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Koichi Kimura, more

World Journal of Surgery > 2019 > 43 > 4 > 1068-1075

Background The relationship between postoperative changes in muscle mass and the prognosis of malignancies remains controversial. We aimed to determine whether a decrease in skeletal muscle mass after surgical resection can predict long-term outcomes in patients with adenocarcinoma of upper stomach (AUS) and esophagogastric junction (AEGJ). Methods We reviewed 146 patients who underwent curative...

article

Survival Outcomes of Two Phase 2 Studies of Adjuvant Chemotherapy with S-1 Plus Oxaliplatin or Capecitabine Plus Oxaliplatin for Patients with Gastric Cancer After D2 Gastrectomy

Yoshiaki Nakamura, Takeharu Yamanaka, Keisho Chin, Haruhiko Cho, more

Annals of Surgical Oncology > 2019 > 26 > 2 > 465-472

Background Two phase 2 trials of oxaliplatin-containing adjuvant therapy for patients with gastric cancer (GC) after D2 gastrectomy were conducted in Japan. The SOXaGC trial evaluated the tolerability and safety of adjuvant therapy with S-1 plus oxaliplatin (SOX), whereas the J-CLASSIC trial evaluated the feasibility of adjuvant therapy with capecitabine plus oxaliplatin (CAPOX). Because both were...

article

Recent research progress on spectrum management approaches in software-defined elastic optical networks

Bijoy Chand Chatterjee, Takehiro Sato, Eiji Oki

Optical Switching and Networking > 2018 > 30 > C > 93-104

The flex-grid technology or elastic optical network (EON) is accepted to be a propitious solution for the future transport network due to its unique properties, which are bandwidth aggregation that creates super wavelength channels, different data rate accommodation, bandwidth segmentation that creates sub-wavelength channels, and elastic variation of assigned bandwidth. The software-defined network...

article

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Yuka Inoue, Nami Yamashita, Hiroyuki Kitao, Kimihiro Tanaka, more

Clinical Breast Cancer > 2018 > 18 > 4 > e643-e650

Wild type p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase magnesium dependent 1 delta (PPM1D), inhibits p53. PPM1D amplification has been reported in breast cancer. Breast cancer can sometimes develop without a tumor protein 53 (TP53) mutation. In these cases, the p53 pathway might be disrupted by alternative mechanisms, and Wip1 is reported to be a key molecule involved.Primary...

article

Non-familial juvenile polyposis of the stomach with gastric cancers: a case report

Tomoko Jogo, Eiji Oki, Minako Fujiwara, Junji Kurashige, more

Surgical Case Reports > 2018 > 4 > 1 > 1-6

Background Juvenile polyposis is an autosomal dominant inherited disease characterized by the development of numerous hamartomatous and nonneoplastic polyps of the gastrointestinal tract. Juvenile polyposis has also recently been reported as a predisposition for gastrointestinal cancer. Case presentation A 63-year-old man underwent esophagogastroduodenoscopy because of anemia and hypoalbuminemia...

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Search results for: Eiji Oki

Joint service placement and user assignment model in multi‐access edge computing networks against base‐station failure

Three‐dimensional imaging of intramural perineural invasion in colorectal cancer: Three‐dimensional reconstruction approach with multiple immunohistochemically stained sections

Histological categorisation of the desmoplastic reaction is a predictor of patient prognosis in oesophageal squamous cell carcinoma

Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses

The evolution of surgical treatment for gastrointestinal cancers

Comparison of computed tomography imaging analyses for evaluation after chemotherapy in patients with colorectal cancer: a retrospective pooled analysis of six phase II clinical trials

CT gastrography “wall-carving technique” of gastric cancer: impact of contrast enhancement based on layer depth

Skeletal muscle loss during systemic chemotherapy for colorectal cancer indicates treatment response: a pooled analysis of a multicenter clinical trial (KSCC 1605-A)

Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report

Approach to problem of minimizing network power consumption based on robust optimization

C‐reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

Amide proton transfer imaging to predict tumor response to neoadjuvant chemotherapy in locally advanced rectal cancer

Primary amelanotic malignant melanoma of the esophagus: a case report

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer

A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2)

Postoperative Skeletal Muscle Loss Predicts Poor Prognosis of Adenocarcinoma of Upper Stomach and Esophagogastric Junction

Survival Outcomes of Two Phase 2 Studies of Adjuvant Chemotherapy with S-1 Plus Oxaliplatin or Capecitabine Plus Oxaliplatin for Patients with Gastric Cancer After D2 Gastrectomy

Recent research progress on spectrum management approaches in software-defined elastic optical networks

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Non-familial juvenile polyposis of the stomach with gastric cancers: a case report

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