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To examine the influence of chronic stress on the brain, we measured local cerebral blood flow in the hippocampus of rats which had been exposed to chronic stress by the hydrogen clearance method in the freely moving status. Rats were exposed, once a day for 12 weeks, to stress of a 15-min immersion in cold water at 4 o C (the stress group) or slightly handled for about 1min (the control group)...
The present study examined the influence of a long-term treatment with glucocorticoid on local cerebral blood flow of the hippocampus in rats, estimated with the hydrogen clearance method. Either a cholesterol (100 mg, as a control) or corticosterone (100 mg) bead was implanted subcutaneously in rats for a period of three months, beginning at 12 weeks of age. The effects of the treatments on the...
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