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The study was designed to study the effect of pentoxifylline PTX on the chemiluminescence response of neutrophils and on tumor necrosis factor-α (TNF-α)-induced priming of neutrophils. The results demonstrate that TNF-α stimulated the respiratory burst by neutrophils and primed them for enhanced response to fMLP but not to PMA. The effect of TNF-α on the oxygen metabolism of neutrophils was inhibited...
Tumour necrosis factor-α (TNF-α) is a potent mediator of inflammation, which exerts profound effects on polymorphonuclear neutrophils (PMN). TNF-α binds to distinct cell surface receptors termed p55 and p75, expressed in approximately equal amounts on the PMN surface. We have studied the effects of TNF-α on the priming of F-Met-Leu-Phe (FMLP)-stimulated oxidative metabolism of PMN, using a luminol-enhanced...
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