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Hypoxia-inducible factor 1 α (HIF-1α) is a transcription factor that was suggested in vitro to promote cell death by modulation of proapoptotic genes. In this report, we tested the hypothesis of an in vivo proapoptotic role of HIF-1α after an ischemic insult. For this purpose, HIF-1α and procaspase-3 mRNA and protein expressions were examined in rat brain subjected to 12- and 24-h permanent focal...
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