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Aims/hypothesis Regeneration and repair mediated by mesenchymal stem cells (MSCs) are key self-protection mechanisms against diabetic complications, a reflection of diabetes-related cell/tissue damage and dysfunction. MSC abnormalities have been reported during the progression of diabetic complications, but little is known about whether a deficiency in these cells plays a role in the pathogenesis...
Objectives Naphthalimides have shown potent antitumour activity against a variety of murine and human cancer cells. However, most of them have been abandoned because of a poor therapeutic index and haematotoxicity, such as amonafide. To overcome these disadvantages, many novel naphthalimide derivatives have been designed and synthesized as antitumour agents.
Methods The cytotoxicity of 6,6‐(propane‐1,3‐diylbis(azanediyl)bis(2‐(2‐(dimethylamino)ethyl)‐1H‐benzo[de]isoquinoline‐1‐3(2H)‐dione)...
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