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Prostaglandin (PG) D 2 exerts multiple actions through interaction with distinct receptors, DP1 and DP2. We have shown that PGD 2 induces the expression of heme oxygenase-1 (HO-1) in the retinal pigment epithelium (RPE) that is essential for survival of photoreceptors. HO-1 is a key enzyme in physiological heme degradation. Here, we explored the mechanism for the PGD 2 -mediated...
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