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This paper introduces a new high-throughput and high-resolution three dimensional tissue scanner with an Internet-connected 3D virtual microscope for large scale automated histology. This instrument is based on a 3D tissue imaging method called Knife Edge Scanning Microscopy (KESM). A prototype instrument was designed and built based on this technology to scan various tissue samples using mouse brain...
Knife Edge Scanning Microscopy (KESM) is a high-throughput imaging technique used to obtain large-scale anatomical information (≈1cm3) at sub-micrometer resolution. Data acquisition has been fully automated, however significant post-processing and reconstruction must be done manually. KESM is unique in that illumination and tissue sectioning are performed using a diamond knife. Therefore many of the...
High-throughput microscopy allows fast imaging of large tissue samples, producing an unprecedented amount of sub-cellular information. The size and complexity of these data sets often out-scale current reconstruction algorithms. Overcoming this computational bottleneck requires extensive parallel processing and scalable algorithms. As high-throughput imaging techniques move into main stream research,...
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