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Cell adhesion and mechanical properties are critical to physiological and pathological processes. Regulation of cell adhesion states is involved in tissue remodeling during morphogenesis and wound healing, cellular metaplasia, cell proliferation and tumor cell metastasis. Cell mechanical properties play an essential role in cell deformation under mechanical forces and other cell functions such as...
Recent studies have demonstrated that acoustic wave devices are capable of quantitatively probing the behaviors of cells on the sensor surface, which has potential applications in biomedical research, environmental contaminant monitoring, drug screening and efficacy testing, and detecting bacteria and viruses in food safety and for anti-bioterrorism. Guided surface acoustic wave (or Love mode) sensor...
Quartz thickness shear mode (TSM) resonators for monitoring the attachment and spreading of mammalian cells have been investigated in the past years. Recent studies have shown that the TSM resonator signal is not only contributed by cellular body closed to the resonator substrate, but also contributed by the extracellular matrix (ECM), which is a protein layer between the cellular body and the resonator...
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