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• Activation of afferents in the posterior femoral cutaneous nerve (PFCN) can reflexively induce efferent firing in the pudendal nerve and pudendal afferent firing via a motor–sensory coupling.
• Activation of pudendal afferent nerves can inhibit the micturition reflex, suggesting PFCN stimulation might also inhibit the micturition reflex.
• This study discovered a somato‐bladder inhibitory reflex...
Non‐technical summary Lower urinary tract disorders including painful and overactive bladder conditions are very difficult to treat. Neuromodulation which is one of the successful therapies for lower urinary tract disorders, stimulates afferent nerves to modulate the neural pathway and achieve a therapeutic effect. We show that the metabotropic glutamate receptor 5 is activated in the central nervous...
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