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A cell, the fundamental unit of life, contains the requisite blueprint information necessary to survive and to build tissues, organs, and systems, eventually forming a fully functional living creature. A slight structural alteration can result in data misprinting, throwing the entire life process off balance. Advances in synthetic biology and cell engineering enable the predictable redesign of biological...
Artificial Cells
In article number 2202962, Yoon‐Kyoung Cho and co‐workers discuss the latest advances in cell membrane‐engineered micro or nanoreactors that simulate biochemical compartments, signaling cascades, energy generation, growth, reproduction, and adaptability. These reactors have the potential to provide hybrid solutions for pharmaceutical drugs, biosensors, novel materials, and biochemical...
Exosomes—nanosized extracellular vesicles (EVs) naturally secreted from cells—have emerged as promising biomarkers and potential therapeutic vehicles, but methods to manipulate them for engineering purposes remain elusive. Among the technical obstacles are the small size and surface complexity of exosomes and the complex processing steps required, which reduce the biocompatibility of currently available...
In article number 1802052, Yoon‐Kyoung Cho and co‐workers report the encapsulation of exosomes with a nanofilm of supramolecular coordination complexes of ferric ion and tannic acid using a droplet‐based microfluidic platform. The “armored exosomes” are well protected against external stress, especially ultra‐violet irradiation and elevated temperature. On‐demand chemical degradation and further surface...
Highly reliable detection, imaging, and monitoring of reactive oxygen species (ROS) are critical for understanding and studying the biological roles and pathogenesis of ROS. This study describes the design and synthesis of myoglobin and polydopamine‐engineered surface‐enhanced Raman scattering (MP‐SERS) nanoprobes with strong, tunable SERS signals that allow for specifically detecting and imaging...
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