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Epigenetic regulation in macrophages plays a crucial role in the inflammatory response of cells. We investigated the role of macrophage histone deacetylase 4 (HDAC4) in diet‐induced obesity and non‐alcoholic steatohepatitis using macrophage‐specific Hdac4 knockout mice (Hdac4MKO). Hdac4 floxed control (Hdac4fl/fl) and Hdac4MKO mice were fed a regular chow diet or an obesogenic high‐fat/high‐sucrose/high‐cholesterol...
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