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The contexts where drugs are self‐administered have important control over relapse and extinction of drug‐seeking behavior. The nucleus accumbens shell (AcbSh) is essential to this contextual control over drug‐seeking behavior. It has been consistently implicated in both the expression of context‐induced reinstatement and the expression of extinction, across a variety of drug classes and other rewards...
The contexts where drugs are self‐administered play an important role in regulating persistent drug taking and in relapse to such taking after periods of abstinence. Here, we review the behavioral and brain mechanisms enabling contexts to promote and prevent relapse to drug seeking. We review the key brain structures, their neuropharmacology and their connectivity. We discuss the similarities and...
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