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We propose an on-chip micromanipulation method based on mode switching of vibration-induced asymmetric flow. The asymmetric flow can be induced around rotationally asymmetric structures on a microfluidic chip by applying a circular vibration to the chip. Thus, the flow pattern can be switched by changing directions of applied vibrations as clockwise or counter-clockwise. In this study, we applied...
We propose an on-chip cell manipulation method for a parallel trapping of single motile cells. The proposed method enables a parallel trapping of large (≳ 50 μm) motile cells, that is difficult to be achieved with conventional cell manipulation methods. We realize the trapping method by using a vibration-induced flow which is induced by applying a vibration to a microfluidic chip having microstructures...
We present a novel cell manipulation method based on vibration-induced flow in open-chip environment. By applying circular vibration to a chip having micropillar patterns on its surface, local whirling flow is induced around the micropillars. Therefore, by patterning micropillar array on a chip and applying the circular vibration to the chip, we can achieve cell transportation along the array in an...
We present a novel cell manipulation method using vibration-induced local flow in open chip environment. By applying circular vibration to micropillars on a chip, local whirling flow is induced around the micropillars. From the observation of this unique phenomenon, we propose the concept of cell manipulation in open chip environment. We analyze this phenomenon theoretically, and evaluate the effect...
In the study of the oocytes/embryos, such as enucleation, microinjection in order to increase the success ratio of the fertilization and characteristics study of the oocytes, all of these research and clinical applications involve 3-D rotation of mammalian oocytes. The gesture or the orientation of the oocyte is critical for improving the enucleation success rate, and characteristics investigation...
This paper describes an innovative driving method for magnetically driven microtools (MMT). 1.1 µm positioning accuracy of the MMT was obtained by applying a piezoelectric ceramic, which induced nanoscale vibration to the microfluidic chip, and reducing the friction on the MMT. Using this drive method, the enucleation process was conducted by dual-arm MMT. Permanent magnets are used to supply the...
The video presents high power, high precision and high speed drive of on-chip robot and its biomedical applications. The magnetically driven microtool (MMT) actuated by permanent magnets was employed as a microrobot because of its strong output force in the order of millinewtons and the ultrasonic vibration was applied to the microfluidic chip in order to reduce the friction on the MMT. We have achieved...
This paper presents innovative driving method for the magnetically driven microtools (MMT) which is micrometer positioning accuracy by horizontally arranged permanent magnets. A piezoelectric ceramic is used to induce nanoscale vibration to the microfluidic chip to reduce the friction on the MMT. The enucleation process has been conducted by the dual arm MMTs. MMTs receive enough driving power supplied...
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