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Aim: The relationship between abnormalities of tubular architecture and tubulointerstitial nephritis antigen (TIN‐ag) in juvenile nephronophthisis (J‐NPH) was evaluated.
Methods: Sixteen J‐NPH patients were examined. Nephrocystin‐1, TIN‐ag, type IV collagen, Fas antigen and the C5b‐9 complement complex were stained by immunohistochemical methods.
Results: Renal tubules of patients with J‐NPH showed...
Tubulointerstitial nephritis antigen (TIN-ag), which has been localized to the renal tubular basement membrane, is a target antigen in some forms of TIN. Physiologically, TIN-ag is thought to be important in maintaining the structure of renal tubular basement membrane. Here we describe a child with chronic renal failure showing a human TIN-ag gene (hTIN-ag) deletion. Immunohistochemical examination...
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