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Existing antibody–drug conjugate (ADC) linkers, whether cleavable or non‐cleavable, are designed to release highly toxic payloads or payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % of the dosed ADCs accumulate in tumour cells. The remaining >99 % of ADCs are nonspecifically distributed in healthy tissue cells, thus inevitably...
Synthesis of highly stable two‐dimensional single‐layer assemblies (SLAs) is a key challenge in supramolecular science, especially those with long‐range molecular order and well‐defined morphology. Here, thin (thickness <2 nm) triangular AuI‐thiolate SLAs with high thermo‐, solvato‐ and mechano‐ stability have been synthesized via a double‐ligand co‐assembly strategy. Furthermore, the SLAs show...