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Antitumor Immunotherapy
In article 2309839, Qinyang Wang and co‐workers have developed a CTL‐inspired system that mimics the process of T‐cells attacking tumour cells. The system delivers chemotherapeutic drugs to cancer cells under the control of NIR light. The researchers found that this killing system enables an ultra‐low dose of chemotherapeutic drugs to trigger pyroptosis‐mediated anti‐tumour...
A Cytotoxic T lymphocyte‐inspired system capable of using ultralow‐dose chemical drugs to manipulate cell death is needed to investigate the antitumor immunotherapy. Recent studies reveal pyroptosis promotes antitumor immune function. However, high‐dose chemotherapy leads to cytokine release syndrome by pyroptosis. Therefore, pyroptosis‐inducing ultralow‐dose chemotherapy is potential in preclinical...