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DNA methylation is an important epigenetic mark relevant to normal development and disease genesis. A common approach to characterizing genome-wide DNA methylation is to use Next Generation Sequencing technology to sequence bisulfite treated DNA. The short sequence reads are mapped to the reference genome to determine the methylation status of Cs. However, despite intense effort, a much smaller proportion...
Next-generation, high-throughput sequencers are now capable of producing hundreds of billions of short sequences (reads) in a single day. The task of accurately mapping the reads back to a reference genome is of particular importance because it is used in several other biological applications, e.g., genome re-sequencing, DNA methylation, and ChiP sequencing. On a personal computer (PC), the computationally...
Background: Genome-wide association studies (GWAS) prove to be a powerful approach to identify the genetic basis of various human diseases. Here we take advantage of existing GWAS data and attempt to build a framework to understand the complex relationships among diseases. Specifically, we examined 49 diseases from all available GWAS with a cascade approach by exploiting network analysis to study...
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