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With 300–500 clinical cases and 1–2 million deaths yearly, malaria contributes to enormous health care and economic burden worldwide. The advent of high throughput -omics technologies is driving new approaches to the identification of potential antimalarial targets. In this paper, we propose a neighborhood subnetwork alignment approach to uncover the network components involved in cell cycle regulation...
Plasmodium falciparum, the causative agent of human malaria, has a dynamic life cycle encompassing the mosquito vector and human hosts. Complex and atypical cell cycles are observed in malaria parasites. Cell cycle related proteins which play important roles in parasite life cycle, but distantly related to host proteins, may serve as desirable drug targets. In this study, based on the principle of...
The development of new antimalarial drugs is urgently needed due to elevated drug resistance in the causative agents Plasmodium parasites. An intervention strategy based on the interruption of the parasite cell cycle could be undertaken using a systems-biology aided drug discovery approach. However, little is known about the components or the mechanism of parasite cell cycle control to date. In this...
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