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Nucleophosmin gene (NPM1) exon 12 is the most common mutated gene found in Acute Myeloid Leukaemia (AML), which is present in 25–35%. NPM1 gene encodes for nucleophosmin (NPM) protein, which contains 294 amino acids. The NPM protein is an abundant nucleolar phosphoprotein that shuttles between the nucleus and cytoplasm. It contributes to promotion of ribosome biogenesis, regulation of centrosomal...
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