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PurposeTo establish the relationship between ALS histopathology and quantitative MRI metrics.
Materials and MethodsALS patients (N = 8) in advanced stages of the disease were enrolled and, immediately after death, the brain of each patient was removed. Freshly excised ALS tissue was imaged at 3.0 Tesla with T1 and T2 mapping protocols and subsequently stained with astrocyte, myelin, and neuronal...
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