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The EORTC 22881-10882 trial in 5178 conservatively treated early breast cancer patients showed that a 16Gy boost dose significantly improved local control, but increased the risk of breast fibrosis. To investigate predictors for the long-term risk of fibrosis, Cox regression models of the time to moderate or severe fibrosis were developed on a random set of 1797 patients with and 1827 patients without...
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