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In vivo terahertz (THz) imaging of human skin needs to be done in reflection geometry due to the high attenuation of THz light by water in the skin. To aid the measurement procedure, there is typically an imaging window onto which the patient places the area of interest. The window enables better pulse alignment and helps keep the patient correctly positioned during the measurement. In this paper,...
The water diffusivity of occluded human stratum corneum (SC) is estimated by standard terahertz reflection spectroscopy and a SC swelling diffusion model. We find that the water diffusivity in occluded skin is higher than that in steady state at the onset of occlusion. This method is potentially useful for non-invasive diagnosis of human skin conditions.
In this paper we show how the act of measuring skin in vivo using a standard terahertz reflection imaging system affects the terahertz response. We found that even 5 seconds occlusion by the imaging window caused subtle changes in the THz response. As the occlusion time increases, the skin's surface water content increases which causes the refractive index of the skin to increase. This in turn leads...
Terahertz light is so strongly absorbed by water that a subtle change in sample water content, be it due to the presence of a medical condition or due to environmental conditions or storage, can affect the terahertz response. This makes it challenging to devise experimental protocols to investigate potential biomedical applications of terahertz imaging and spectroscopy. In this work we detail some...
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