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Massive amounts of sequencing data are being generated thanks to advances in sequencing technology and a dramatic drop in the sequencing cost. Much of the raw data are comprised of nucleotides and the corresponding quality scores that indicate their reliability. The latter are more difficult to compress and are themselves noisy. Lossless and lossy compression of the quality scores has recently been...
The amount of information lost in sub-Nyquist sampling of a continuous-time Gaussian stationary process is quantified. We consider a combined source coding and sub-Nyquist reconstruction problem in which the input to the encoder is a noisy sub-Nyquist sampled version of the analog source. We first derive an expression for the mean squared error in the reconstruction of the process from a noisy and...
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