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Background
5‐Hydroxytryptamine (5‐HT) could play a role in alleviating symptoms in constipation. However, the mechanism underlying the role of intestinal flora in the promotion of 5‐HT secretion by enterochromaffin cells (ECs) and regulation of the gastrointestinal endocrine system remains unclear.
Methods
A constipation mouse model was constructed, and the 5‐HT, chromogranin A (CGA), substance...