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Models of biochemical reaction networks can be decomposed into a stoichiometric part and a kinetic part. The stoichiometric part describes the structural mass flows while the kinetic part describes how the flow rates vary with substrate concentrations and regulatory interactions. Herein a method for analyzing the robustness of biochemical networks with respect to perturbations of the kinetic part...
Bi- or even multistable behavior is a recurrent phenomenon in gene regulation networks. These networks have the capacity to operate in two or more distinct modes in a stable manner. In this work, we consider gene regulation networks with known interaction structure but unknown reaction kinetics. Additionally, it is assumed that several distinct operation modes were observed experimentally whereby...
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