Search results for: Jiankang Zhang

Items from 1 to 20 out of 71 results

article

Synergistic Interaction between Metal Single‐Atoms and Defective WO₃₋_x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Zhan Zhou, Tao Wang, Tingting Hu, Hao Xu, more

Advanced Materials > 36 > 23 > n/a - n/a

Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of metal SAs on oxygen vacancy (OV)‐rich WO₃₋_x nanosheets to generate a synergistic effect for efficient SDT is reported. Crystalline WO₃ and OV‐rich WO₃₋_x nanosheets are...

article

Mechanistic Insight into the Synergy between Platinum Single Atom and Cluster Dual Active Sites Boosting Photocatalytic Hydrogen Evolution

Jiankang Zhang, Yukun Pan, Dan Feng, Lin Cui, more

Advanced Materials > 35 > 25 > n/a - n/a

In the energy transition context, the design and synthesis of high‐performance Pt‐based photocatalysts with low Pt content and ultrahigh atom‐utilization efficiency for hydrogen production are essential. Herein, a facile approach for decorating atomically dispersed Pt cocatalysts having single‐atom (SA) and atomic cluster (C) dual active sites on CdS nanorods (Pt_SA+C/CdS) via atomic layer deposition...

article

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

Jiankang Zhang, Haitao Shi, Nian Zhang, Liru Hu, more

Cell Proliferation > 53 > 10 > n/a - n/a

Objective Tissue engineering is a promising strategy for repair of large bone defect. However, the immune system reactions to biological scaffold are increasingly being recognized as a crucial factor influencing regeneration efficacy. In this study, a bone‐bioactive hydrogel bead loaded with interleukin‐4 (IL‐4) was used to regulate macrophages polarization and accelerate bone regeneration. Methods...

article

Motivating role of type H vessels in bone regeneration

Jiankang Zhang, Jian Pan, Wei Jing

Cell Proliferation > 53 > 9 > n/a - n/a

Coupling between angiogenesis and osteogenesis has an important role in both normal bone injury repair and successful application of tissue‐engineered bone for bone defect repair. Type H blood vessels are specialized microvascular components that are closely related to the speed of bone healing. Interactions between type H endothelial cells and osteoblasts, and high expression of CD31 and EMCN render...

article

The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo

Rui He, Qin Li, Wenqi Shen, Tao Wang, more

International Wound Journal > 17 > 3 > 851 - 863

Cold atmospheric plasma (CAP) is a group of various chemical active species, such as ozone and nitric oxide, generated by working gas. CAP was demonstrated to have an effect on tissue regeneration and wound healing. We conducted this study to evaluate the efficacy and safety of CAP as a novel therapy for diabetic wounds in vitro and in vivo. The plasma consists of ionised helium gas that is produced...

article

Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents

Jiankang Zhang, Jianjun Xi, Ruoyu He, Rangxiao Zhuang, more

Medicinal Chemistry Research > 2019 > 28 > 10 > 1633-1647

A series of novel 3-(thiophen/thiazole-2-ylthio)pyridine derivatives were designed and synthesized as IGF-1R tyrosine kinase inhibitors. All the target compounds were tested for their IGF-1R kinase inhibitory activities and cytotoxicities against five cancer cell lines (K562, Hep-G2, HCT-116, WSU-DLCL2, and A549). Although all these compounds exhibited moderate to potent cancer cell proliferation...

article

Compressed sensing based loss tomography using weighted ℓ1 minimization

XiaoBo Fan, Xingming Li, JianKang Zhang

Computer Communications > 2018 > 127 > C > 122-130

Network tomography allows the measurements of end-to-end to infer network internal links characteristics such as packet loss rates and delay. In this paper, we focus on the problem of estimating links loss rates, especially locating the congested links in network. Applying concepts of compressed sensing and Maximum A-Posteriori (MAP) estimation, we propose a new loss tomography scheme. Contrary to...

article

Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts

Xiaodong Ma, Xiaoqing Lv, Jiankang Zhang

European Journal of Medicinal Chemistry > 2018 > 143 > C > 449-463

Polypharmacology has been increasingly advocated for the therapeutic intervention in complex pathological conditions, exemplified by cancer. Although kinase inhibitors (KIs) have revolutionized the treatment for certain types of malignancies, some major medical needs remain unmet due to the relentless advance of drug resistance and insufficient efficacy of mono-target KIs. Hence, “multiple targets,...

chapter

Interference channel state based user-centric cell clustering for uplink multicell cooperation

Zhe Zhang, Ning Wang, Jiankang Zhang, Jin Jin, more

2017 9th International Conference on Wireless Communications and Signal Processing (WCSP) > 1 - 5

2017 9th International Conference on Wireless Communications and Signal Processing (WCSP)

Cooperative receiving has been recognized as an effective technique to mitigate inter-cell interference (ICI) for the uplink of multicell wireless systems. However, how to cluster the cooperative cells effectively is critical to the subsequent multicell signal processing and the corresponding performance improvement. A dynamic user-centric clustering scheme based on the interference channel strength...

chapter

Antenna grouping assisted spatial modulation for massive MIMO systems

Xingxuan Zuo, Jiankang Zhang, Xiaomin Mu

2017 9th International Conference on Wireless Communications and Signal Processing (WCSP) > 1 - 6

2017 9th International Conference on Wireless Communications and Signal Processing (WCSP)

In this paper, an antenna grouping assisted spatial modulation scheme is proposed for massive MIMO systems. Massive multiple-input-multiple-output (MIMO) systems are capable of offering abundant spatial capacity by deploying hundreds of antennas at the base station (BS). Spatial modulation (SM) is one of the key technologies in exploiting spatial capacity, which maps the information bits to the active...

article

Flexible design of gradient multilayer nanofilms coated on carbon nanofibers by atomic layer deposition for enhanced microwave absorption performance

Shichao Zhao, Lili Yan, Xiaodong Tian, Yequn Liu, more

Nano Research > 2018 > 11 > 1 > 530-541

Impedance matching is important for achieving high-efficiency microwave absorbers. The high conductivity of dielectric loss materials such as pure metals and carbon nanomaterials generally results in poor absorption owing to the low impedance matching between the absorbers and air. Carbon nanostructures are very promising candidates for high-efficiency absorption because of their attractive features...

chapter

Cooperation resource efficient user-centric clustering for QoS provisioning in uplink CoMP

Zhe Zhang, Ning Wang, Jiankang Zhang, Xiaomin Mu, more

2017 IEEE 18th International Workshop on Signal Processing Advances in Wireless Communications (SPAWC) > 1 - 5

2017 IEEE 18th International Workshop on Signal Processing Advances in Wireless Communications (SPAWC)

In this paper, user-centric clustering for uplink coordinated multi-point (CoMP) processing in a multi-cell environment is investigated such that the inter-cell interference (ICI) within cluster can be effectively eliminated. Although full cooperation among all cells in the network can achieve the highest cooperative gain in terms of ICI cancellation, such scheme consumes too much cooperation resources...

article

Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors

Yanmei Zhao, Jiankang Zhang, Rangxiao Zhuang, Ruoyu He, more

Bioorganic & Medicinal Chemistry > 2017 > 25 > 12 > 3195-3205

In this study, a series of novel pyridine and pyrimidine-containing derivatives were designed, synthesized and biologically evaluated for their c-Met inhibitory activities. In the biological evaluation, half of the target compounds exhibited moderate to potent c-Met inhibitory activities. Among which, it is noteworthy that compounds 13d not only showed most potent c-Met inhibitory potency but also...

article

Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors

Jiankang Zhang, Xiaoqing Lv, Xiaodong Ma, Yongzhou Hu

European Journal of Medicinal Chemistry > 2017 > 127 > C > 509-520

Recently, the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been considered as promising targets for the treatment of cancer. Herein, we synthesized a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as novel PI3K/mTOR dual inhibitors for cancer therapy. In the biological evaluation, compound 17e was identified as a potent PI3K/mTOR dual inhibitor, which...

article

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors

Rangxiao Zhuang, Lixin Gao, Xiaoqing Lv, Jianjun Xi, more

European Journal of Medicinal Chemistry > 2017 > 126 > C > 1056-1070

A series of novel piperazine or piperidine-containing non-covalent peptidyl derivatives possessing a neopentyl-asparagine residue were designed, synthesized and evaluated as proteasome inhibitors. All target compounds were screened for their 20S proteasome chymotrypsin-like inhibitory activities, and 15 ones displayed more potent activities than carfilzomib with IC₅₀ values lower than 10 nM. Subsequently,...

article

Porous TiO₂ Nanotubes with Spatially Separated Platinum and CoO_x Cocatalysts Produced by Atomic Layer Deposition for Photocatalytic Hydrogen Production

Jiankang Zhang, Zhuobin Yu, Zhe Gao, Huibin Ge, more

Angewandte Chemie International Edition > 56 > 3 > 816 - 820

Efficient separation of photogenerated electrons and holes, and associated surface reactions, is a crucial aspect of efficient semiconductor photocatalytic systems employed for photocatalytic hydrogen production. A new CoO_x/TiO₂/Pt photocatalyst produced by template‐assisted atomic layer deposition is reported for photocatalytic hydrogen production on Pt and CoO_x dual cocatalysts. Pt nanoclusters...

article

Porous TiO₂ Nanotubes with Spatially Separated Platinum and CoO_x Cocatalysts Produced by Atomic Layer Deposition for Photocatalytic Hydrogen Production

Jiankang Zhang, Zhuobin Yu, Zhe Gao, Huibin Ge, more

Angewandte Chemie > 129 > 3 > 834 - 838

article

Two-Stage Time-Domain Pilot Contamination Elimination in Large-Scale Multiple-Antenna Aided and TDD Based OFDM Systems

Xinying Guo, Jiankang Zhang, Sheng Chen, Xiaomin Mu, more

IEEE Access > 2017 > 5 > 8629 - 8641

Pilot contamination (PC) is a major impediment of large-scale multi-cell multiple-input multiple-output systems. Hence, we propose an optimal pilot design for time-domain channel estimation, which is capable of completely eliminating PC. More specifically, a sophisticated combination of downlink training and “scheduled” uplink training is designed with the aid of the optimal pilot set. Given the optimal...

article

Discrete Multi-Tone Digital Subscriber Loop Performance in the Face of Impulsive Noise

Tong Bai, Hongming Zhang, Rong Zhang, Lie-Liang Yang, more

IEEE Access > 2017 > 5 > 10478 - 10495

As an important solution to “the last mile” access, digital subscriber loops (DSLs) are still maintained in a huge plant to support low-cost but high-quality broadband network access through telephone lines. The discrete multi-tone (DMT) transmissions constitute a baseband version of the ubiquitous orthogonal frequency division multiplexing. While the DMT is ideally suited to deal with the frequency...

article

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors

Jiankang Zhang, Lixin Gao, Jianjun Xi, Li Sheng, more

Bioorganic & Medicinal Chemistry > 2016 > 24 > 23 > 6206-6214

A series of novel non-covalent piperidine-containing dipeptidyl derivatives were designed, synthesized and evaluated as proteasome inhibitors. All target compounds were tested for their proteasome chymotrypsin-like inhibitory activities, and selected derivatives were evaluated for the anti-proliferation activities against two multiple myeloma (MM) cell lines RPMI 8226 and MM-1S. Among all of these...

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CHANNEL ESTIMATION (18)
OFDM (16)
MIMO (9)
MULTIUSER DETECTION (6)
OFDM MODULATION (6)
VECTORS (6)
ANTI-CANCER (5)
ATOMIC LAYER DEPOSITION (5)
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TRAINING (5)
JOINTS (4)
MATHEMATICAL MODEL (4)
PROTEASOME INHIBITORS (4)
UPLINK (4)
ANTENNA ARRAYS (3)
EQUATIONS (3)
ESTIMATION (3)
EXPECTATION-MAXIMISATION ALGORITHM (3)
FORWARD ERROR CORRECTION (3)
MAXIMUM LIKELIHOOD ESTIMATION (3)
MIMO COMMUNICATION (3)
MODULATION (3)
MULTI-CELL SYSTEMS (3)
OFDM SYSTEMS (3)
ORTHOGONAL FREQUENCY-DIVISION MULTIPLEXING (OFDM) (3)
PILOT CONTAMINATION (3)
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RECEIVERS (3)
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SPACE-DIVISION MULTIPLE ACCESS (SDMA) (3)
TIME DIVISION DUPLEXING (3)
ALGORITHM DESIGN AND ANALYSIS (2)
ANGIOGENESIS (2)
ANTENNA GROUPING (2)
ARRAY SIGNAL PROCESSING (2)
BOOSTING (2)
CHANNEL IMPULSE RESPONSE (2)
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COMPRESSED SENSING (2)
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CONTAMINATION (2)
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DATA MODELS (2)
DECODING (2)
DISPERSION (2)
EPOXYKETONE (2)
HVDC TRANSMISSION (2)
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INTERFACES (2)
ITERATIVE DECODING (2)
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MIMO OFDM/SDMA SYSTEMS (2)
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OSTEOGENESIS (2)
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SARS (2)
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$\LAMBDA$ -SYSTEM. (1)
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INFONA - science communication portal

Search results for: Jiankang Zhang

Synergistic Interaction between Metal Single‐Atoms and Defective WO₃₋_x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Mechanistic Insight into the Synergy between Platinum Single Atom and Cluster Dual Active Sites Boosting Photocatalytic Hydrogen Evolution

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

Motivating role of type H vessels in bone regeneration

The efficacy and safety of cold atmospheric plasma as a novel therapy for diabetic wound in vitro and in vivo

Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents

Compressed sensing based loss tomography using weighted ℓ1 minimization

Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts

Interference channel state based user-centric cell clustering for uplink multicell cooperation

Antenna grouping assisted spatial modulation for massive MIMO systems

Flexible design of gradient multilayer nanofilms coated on carbon nanofibers by atomic layer deposition for enhanced microwave absorption performance

Cooperation resource efficient user-centric clustering for QoS provisioning in uplink CoMP

Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors

Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors

Porous TiO₂ Nanotubes with Spatially Separated Platinum and CoO_x Cocatalysts Produced by Atomic Layer Deposition for Photocatalytic Hydrogen Production

Porous TiO₂ Nanotubes with Spatially Separated Platinum and CoO_x Cocatalysts Produced by Atomic Layer Deposition for Photocatalytic Hydrogen Production

Two-Stage Time-Domain Pilot Contamination Elimination in Large-Scale Multiple-Antenna Aided and TDD Based OFDM Systems

Discrete Multi-Tone Digital Subscriber Loop Performance in the Face of Impulsive Noise

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors

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