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Data-driven respiratory gating was previous developed to extract respiratory information directly from PET listmode data. It was also shown that different regions may contribute differently to the accuracy of the motion signal, affecting the successful rate of this method. The goal of this study is to develop and evaluate methods that automatically determine the optimum regions to acquire respiratory...
Patient motion can cause image blurring effects and mismatch of attenuation maps during a brain scan. To detect and correct patient head movement during a PET scan, external devices are usually used. The goal of this study is to present a method that automatically detects and corrects rigid patient motion in real time, without any additional external device using only the listmode data. Within each...
Time-of-Flight (TOF) PET data determines the attenuation map up to a constant. MLAA (Maximum Likelihood Activity and Attenuation Estimation) was proposed for this purpose. However, in real systems the estimated attenuation map usually results in bias and artifacts, due to various factors such as non-uniform timing resolution, detector timing drift, and biased scatter estimation. Moreover, MLAA has...
Data-driven respiratory gating techniques in cardiac PET extract respiratory motion signal from the PET data to guide respiratory gating and motion estimation. However, the influence of the quality of the list-mode data including the uptake ratio between the myocardium and background and the detected count level on its performance has never been studied thoroughly. In this project, list-mode PET data...
Positron emission tomography (PET) using F-18 sodium fluoride (NaF) has been investigated as an imaging biomarker for coronary vulnerable plaque. The goal of this work is to study the effects of activity uptake of the plaque, image noise, respiratory and cardiac motion, and respiratory and cardiac gating techniques on the detectability of coronary artery plaques through a realistic simulation study...
To investigate the predictive value of minor salivary gland biopsy in clinically diagnosed early stage Parkinson’s disease (PD) patients, and to provide more evidence of minor salivary gland biopsy as a pathological diagnostic biomarker of PD. Thirteen patients with early stage PD and 13 age-matched controls were recruited. Hoehn and Yahr stage and Unified Parkinson’s disease Rating Scale Part III...
The current work was based on a previously developed 4D image reconstruction method for myocardial perfusion (MP) PET where dual respiratory motion (RM) and cardiac motion (CM) compensation were performed post reconstruction. We implemented and extended the work on patient data from a commercial PET system and demonstrated further image quality improvement. We divided the PET events into 6 equal-count...
The goal of this study is to develop and evaluate two 4D statistical iterative image reconstruction (SIIR) methods with respiratory motion (RM) and cardiac motion (CM) compensation for improving the detection of motion defects in 4D gated cardiac PET. The first 4D SIIR method, motion correction after reconstruction (MCAR) was developed previously, where the dual RM&CM compensation was achieved...
Respiratory motion is one image degradation factor that affects the resolution and may cause artifacts in PET imaging. Respiratory gating technique is able to reduce the blurring effects but results in higher noise level. Conventional motion correction methods that model motion effects during or after image reconstruction not only increases reconstruction time, but also requires a gated or blurred...
Accurate estimation of cardiac motion from clinical medical images especially motion components parallel to edges has been found to be difficult using the intensity based optical flow algorithm without any prior information. This research aims to develop a new feature guided cardiac motion estimation method for gated myocardial perfusion (MP) PET images whose quality has greatly improved in recent...
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