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The aim of this study was to optimize the culture conditions of a marine‐derived fungus Penicillium sclerotiorum M‐22 for the production of penicilazaphilone C (PAC), a novel azaphilonidal derivative exhibiting broad cytotoxic and antibacterial effects. By single factor experiments, the effects to the production of PAC of aged seawater concentration, initial pH values, fermentation time, carbon sources,...
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