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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N‐methyl‐d‐aspartate receptors (NMDARs) leading to excitotoxicity. Recently, we demonstrated that amyloid‐beta oligomers (AβO), the species implicated in synaptic...
Cdk5 dysregulation is a major event in the neurodegenerative process of Alzheimer’s disease (AD). In vitro studies using differentiated neurons exposed to Aβ exhibit Cdk5‐mediated tau hyperphosphorylation, cell cycle re‐entry and neuronal loss. In this study we aimed to determine the role of Cdk5 in neuronal injury occurring in an AD mouse model obtained through the intracerebroventricular (icv) injection...
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