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R‐loops and G‐quadruplexes (G4s) are noncanonical secondary DNA structures. Here, we show that reactive oxygen species (ROS) induce G4 formation as well as R‐loops at transcriptionally active sites. Importantly, the G4 structure is subsequently triggered by R‐loop formation after damage. Once G4 is formed within an R‐loop, it reversely stabilizes the R‐loop. Notably, the helicase activity of Bloom...
Estrogen depletion following menopause has been correlated with an increased risk of developing Alzheimer’s disease (AD). We previously explored the beneficial effect of (−)-epigallocatechin-3-gallate (EGCG) on AD mice and found increased non-amyloidogenic processing of amyloid precursor protein (APP) through the α-secretase a disintegrin and metallopeptidase domain 10 (ADAM10). Our results in this...
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