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Objective
There are currently no good histological or molecular markers to differentiate benign from malignant phaeochromocytomas and paraganglinomas (PPGLs). Our previous cross‐sectional study observed that ERBB‐2 overexpression was associated with malignant PPGLs. This study aimed to evaluate the predictive value of ERBB‐2 overexpression for metastasis in PPGLs in a large population.
Methods...
ObjectivePhaeochromocytomas (PHEO) and functional paragangliomas (PGLs) are catecholamine‐secreting neuroendocrine tumours. Although most PHEO/PGLs are benign, 10–35% present as (or develop into) malignant tumours with a poor prognosis. Overexpression of ERBB2 (v‐erb‐b2 erythroblastic leukaemia viral oncogene homologue 2) has been reported to be associated with malignant PHEO. We used gene expression...
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