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Terahertz (THz) spectral properties of human cornea are explored as a function of central corneal thickness (CCT) and corneal water content, and the clinical utility of THz-based corneal water content sensing is discussed. Three candidate corneal tissue water content (CTWC) perturbations, based on corneal physiology, are investigated that affect the axial water distribution and total thickness. The...
Electromagnetic modeling predicts that dielectric substrate windows placed above a tissue of interest alter the hydration sensitivity of reflective THz imaging systems. Furthermore, interference effects between layers (the window with the skin layers) cause the window's optical path length to change the depth probed by the imaging system. A pulsed THz imaging system operating at ∼ 500 GHz was used...
Variations in water volume fraction have been investigated as a possible source of contrast in several reflective THz medical imaging applications including corneal hydration sensing and burn wound severity diagnosis. Due to surface roughness and non-planar geometry most reflective systems employ low loss windows such as quartz or sapphire to minimize the effects of the specimen's topology. This creates...
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