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Research into the application of THz frequency imaging to medical diagnostics has yielded a significant body of work reporting the properties of in vitro and ex vivo samples. However, there a dearth of in vivo imaging results owing to the practical difficulties of acquiring data of sufficient fidelity on living animal and/or human subjects. This limited data set has hindered widespread acceptance...
Electromagnetic modeling predicts that dielectric substrate windows placed above a tissue of interest alter the hydration sensitivity of reflective THz imaging systems. Furthermore, interference effects between layers (the window with the skin layers) cause the window's optical path length to change the depth probed by the imaging system. A pulsed THz imaging system operating at ∼ 500 GHz was used...
THz medical imaging has made significant advances in the years since the first results were published in the late 1990s. The field has benefited significantly from advances in source/detector technology, room temperature component operation, and extensive spectroscopic studies of the THz properties of tissue. Additionally, clinical translation of THz medical imaging technology has been aided by the...
Variations in water volume fraction have been investigated as a possible source of contrast in several reflective THz medical imaging applications including corneal hydration sensing and burn wound severity diagnosis. Due to surface roughness and non-planar geometry most reflective systems employ low loss windows such as quartz or sapphire to minimize the effects of the specimen's topology. This creates...
The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at 525 GHz center frequency with 125 GHz of response normalized...
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