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This study was designed to examine the roles of intracellular free magnesium ion concentration ([Mg2+]i) in ethanol-induced intoxication and development of tolerance in cultured canine cerebral vascular smooth muscle cells and astrocytes as well as intact rat brain. The basal, resting level of [Mg2+]i in cerebrovascular cells was 732.5 ± 82.4 μM. Exposure of cultured canine cerebral vascular smooth...
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