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B-cell epitopes play an important role for developing synthetic peptide vaccines and inducing antibody responses. Applying biological experiments for epitope identification is time consuming and demands a lot of experimental resources. Nevertheless, it is important yet challenging task for designing a computer-aided B-cell linear epitope prediction system with high precision rates. In this paper,...
Internal repeats are widely found in proteins and considered to be important in protein evolution and function. Three major types of internal repeat including domain, solenoid, and fibrous repeats are. These repeats may involve in protein-protein interaction as well as binding to various ligands such as DNA and RNA. For example, the tetratrico peptide repeats (TPR) that are involved in cell-cycle...
We describe a new approach for inferring the functional relationships between nonhomologous protein families by looking at statistical enrichment of alternative function predictions in classification hierarchies such as Gene Ontology (GO) and Structural Classification of Proteins (SCOP). Protein structures are represented by robust graph representations, and the fast frequent subgraph mining algorithm...
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