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Type I interferon system is essential for anti-viral immune response and is a primary target of viral immune evasion strategies. Influenza A viruses mainly utilize the non-structural protein 1 (NS1) to suppress host immune responses, especially the type I interferon system. Here, we showed influenza infection induces the expression of MAP kinase phosphatase 5 (MKP5), a member of MAP kinase phosphatase...
Dual specificity phosphatases (DUSPs) have been shown to play a critical role in regulation of various cellular processes and aberrations in their expression patterns are associated with pathogenesis of wide range of diseases. The atypical dual-specificity phosphatase DUSP11 was previously demonstrated to bind to ribonucleic acid–ribonucleoprotein (RNA–RNP) complexes and RNA-splicing factors and is...
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