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Abstract
Herbal supplements can cause hepatotoxicity and drug interactions via hepatic cytochrome P‐450 (CYP) in some cases. However, there is no simple and stable cell‐based assay to conduct a screening for hepatotoxicity and CYP induction. In the present study, we selected 14 components of the herbal supplement based on our previous reports and investigated the safety of the herbal supplement components...
We evaluated the influence of pine bark extract (PBE) on organs, the cytochrome‐P450 (CYP) activities in liver and estrogenic effects in normal and ovariectomized (OVX) female mice. The PBE did not affect organ weights and liver‐function indexes (activities of alkaline phosphatase, aspartate amino transferase, and alanine amino transferase) at doses; 0.04%, 0.4%, and 2.0% PBE in the diet, in normal...
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