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T cells are key players of the mammalian adaptive immune system. They experience different mechanical microenvironments during their life cycle, from the thymus, secondary lymph organs, and peripheral tissues that are free of externally applied force, but display variable substrate rigidities to the blood and lymphatic circulation systems, where complicated hydrodynamic forces are present. Regardless...
Recognition of peptide presented by the major histocompatibility complex (pMHC) molecule by the T‐cell receptor (TCR) determines T‐cell selection, development, differentiation, fate, and function. Despite intensive studies on the structures, thermodynamic properties, kinetic rates, and affinities of TCR–pMHC interactions in the past two decades, questions regarding the functional outcome of these...
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