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N6‐methyladenosine (m6A) modulators decide the fate of m6A‐modified transcripts and drive cancer development. RNA interference targeting m6A modulators promise to be an emerging cancer therapy but is challenging due to its poor tumor targeting and high systematic toxicity. Here engineered small extracellular vesicles (sEVs) with high CD47 expression and cyclic arginine–glycine–aspartic (c(RGDyC))...
Engineered Extracellular Vesicles
In article number 2204910, Jia Yu, Yanlian Yang, Ling Zhu, and co‐workers report an extracellular‐vesicle‐based nanodrug for the targeting delivery of short interfering RNA (siRNA) against N6‐methyladenosine (m6A) reader YTH N6‐methyladenosine RNA binding protein 1 (YTHDF1) for the epigenetic and immune regulation of gastric cancer. This versatile nanoplatform provides...
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