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Purpose To investigate the role of in situ generated fine excipient particles on the fluidization and aerosolization properties of dry powder inhaler (DPI) formulations. Materials and Methods Carrier based DPI formulations were prepared under low and high shear blending. Powder rheometery was utilized to measure bulk powder properties in a consolidated and aerated state. Powder fluidization and...
Purpose. The objective was to develop a single-step pharmaceutical particle engineering technique able to produce particles within a well-defined particle size range while controlling macroscopic spherical morphology and mesoscopic surface topography. Methods. Paracetamol (acetaminophen) aerosol droplets were generated by spraying a solution via either an electrohydrodynamic atomizer (EHDA)...
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