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The cell elimination strategy based on reactive oxygen species (ROS) is a promising method for tumor therapy. However, its efficacy is significantly limited by ROS deficiency caused by H2O2 substrate deficiency and up‐regulation of cellular antioxidant defense induced by high glutathione (GSH) content in tumor cells. To overcome these obstacles, a multifunctional self‐cascaded nanocomposite: glucose...
Ferroptosis‐related renal tubular lesions play important roles in diabetic kidney disease (DKD) progression, and these pathophysiological responses are collectively described as diabetic tubulopathy (DT), which lacks an effective treatment. Total flavones from Abelmoschus manihot (TFA), a natural extract that extensively used in patients with chronic kidney disease, has been used for treatment of...
The combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water‐in‐oil Pickering emulsion gel is developed to deliver (1S, 3R)‐RSL‐3 (RSL‐3), a ferroptosis inducer dissolved in iodized oil, and programmed death‐1 (PD‐1) antibody, the most commonly used...