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A novel minimally invasive way to measure blood glucose concentration is proposed by combining interstitial fluid (ISF) transdermal extraction and surface plasmon resonance (SPR) detection. 55 kHz low-frequency ultrasound pulses are applied for 30 seconds to enhance the skin permeability and then interstitial fluid is extracted out of skin by vacuum. The glucose concentration in the interstitial fluid...
A novel minimally invasive way to measure the diabetic's real-time blood glucose concentration in vitro is proposed by combining interstitial fluid transdermal extraction ultrasonically and surface plasma resonance detecting. Low-frequency ultrasound is employed to enhance the skin permeability to interstitial fluid by disrupting the stratum corneum lipid bilayers and then interstitial fluid is extracted...
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