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Myotubularin and myotubularin‐related proteins are evolutionarily conserved in eukaryotes. Defects in their function result in muscular dystrophy, neuronal diseases and leukemia in humans. In contrast to the animal lineage, where genes encoding both active and inactive myotubularins (phosphoinositide 3‐phosphatases) have appeared and proliferated in the basal metazoan group, myotubularin genes are...
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