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Purified from Bauhinia rufa seeds, BrTI is a Kunitz proteinase inhibitor that contains the RGD sequence. BrTI inhibits trypsin (K iapp 2.9nM) and human plasma kallikrein (K iapp 14.0nM) but not other related enzymes. The synthetic peptide YLEPVARGDGGLA-NH 2 (70μM) inhibited the adhesion to fibronectin of B16F10 (high-metastatic B16 murine mouse melanoma cell line) and of Tm5...
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