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The 3C protease (3C Pro) plays a significant role in the life cycle of picornaviruses from replication to translation, making it an attractive target for structure‐based design of drugs against picornaviruses. The structurally related 3C‐like protease (3CL Pro) is an important protein involved in the replication of coronaviruses. With the emergence of COVID‐19 and consequent intensive research into...
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