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A considerable number of studies have demonstrated that nicotine, a α7-nicotinic acetylcholine receptor (α7-nAChR) agonist, can dampen immune response through the cholinergic anti-inflammatory pathway. Evidence suggests that inflammation plays a critical role in eclampsia, which contributes to maternal and fetal morbidity and mortality.In the present study, possible anti-inflammation and neuro-protective...
Pre-eclampsia is characterized by new-onset hypertension and proteinuria at ⩾20weeks of gestation. Our previous study demonstrated that the cholinergic anti-inflammatory pathway may contribute to the relief of Pre-eclampsia through α7 nicotinic acetylcholine receptor (α7 nAChR). Choline, a selective α7 nAChR agonist, has recently been established as a promising treatment for inflammation.In order...
Pre-eclampsia (PE) exerts more intense systemic inflammatory response than normal pregnancy. We have demonstrated that the cholinergic anti-inflammatory pathway may contribute to the relief of Pre-eclampsia through α7 nicotinic acetylcholine receptor (α7 nAChR). Furthermore, choline, an essential nutrient that is meanwhile a selective α7 nAChR agonist, has been proved to prevent LPS-induced preeclampsia...
Eclampsia is defined as the development of seizure during pregnancy or postpartum in patients with signs and symptoms of preeclampsia. In general, the hypothesis that inflammation contributes to seizures is supported by some studies. In this study we will observe the effects of Cyclosporin A (CsA) in an eclampsia-like rat model.Rats were administered lipopolysaccharide (1.0 mg/kg) by tail vein injection...
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