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Genomewide association studies (GWASs) typically require a base of linkage disequilibrium (LD) to capture quantitative trait locus (QTL) signals. In this study, we tested whether identifying QTLs in the framework of GWAS can be based only on linkage information. Our study sought to validate a method to replace LD with linkage in association studies, and we investigated the statistical power of different...
The ‘large p, small n’ problem in genomewide association studies (GWAS) is an important subject in genetic studies. Many approaches have been proposed for this issue, but none of them successfully combine the Haseman–Elston (H–E) regression with sliding-window scan approaches in GWAS. In this article, we extended H–E regression to GWAS, and replaced original data with different measurements of phenotype...
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