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An international team spanning 19 sites across 18 biopharmaceutical and in vitro diagnostics companies in the United States, Europe, and China, along with one regulatory agency, was formed to compare the precision and robustness of imaged CIEF (ICIEF) for the charge heterogeneity analysis of the National Institute of Standards and Technology (NIST) mAb and a rhPD‐L1‐Fc fusion protein on the iCE3 and...
DOI: 10.1002/elps.202100348
The back cover picture shows the iCE3 and Maurice instruments used to demonstrate the comparability of the instruments for measuring charge heterogeneity in mAbs and fusion proteins by icIEF. Also shown is a representative electropherogram of the fusion protein obtained on the instruments. Previous studies evaluating icIEF for measuring charge heterogeneity have utilized...
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